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Clin Infect Dis. 2003 Sep 1;37(5):728-32. Epub 2003 Aug 7.

Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients.

Author information

1
Pfizer, Sandwich, UK. Irja_Lutsar@sandwich.pfizer.com

Abstract

We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 microg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 (median, 0.46).

PMID:
12942409
DOI:
10.1086/377131
[Indexed for MEDLINE]

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