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Nat Immunol. 2003 Sep;4(9):835-42.

Similarities and differences in CD4+ and CD8+ effector and memory T cell generation.

Author information

1
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3005, USA. rseder@mail.nih.gov

Abstract

Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.

PMID:
12942084
DOI:
10.1038/ni969
[Indexed for MEDLINE]

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