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Curr Opin Microbiol. 2003 Aug;6(4):399-405.

Contributions of vesicular stomatitis virus to the understanding of RNA virus evolution.

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Department of Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave., Toledo 43614, OH, USA.


Vesicular stomatitis virus has been a preferred system to study evolution for several decades. New approaches to antiviral treatment, such as lethal mutagenesis, stem from investigations done with VSV. Recent work has shed new light in the way we view neutrality, a fundamental concept to understand the evolutionary history of RNA viruses.

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