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Curr Opin Microbiol. 2003 Aug;6(4):338-43.

Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hosts.

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Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.


Although morphological flexibility could be a key contributor to fungal virulence, no molecular data has unambiguously established fungal morphogenesis as a virulence factor for Candida albicans, nor can specific forms of Candida be regarded as absolutely indicative of saprophytism or infection at a given site on the host. The fitness of the fungus in vivo probably reflects its adaptation to the variety of microenvironments in which this opportunist must survive.

[Indexed for MEDLINE]

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