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Microbes Infect. 2003 Sep;5(11):961-8.

Viruses and Toll-like receptors.

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Department of Microbiology/Cancer Center, University of Pennsylvania, 313 BRBII/III, 421, Curie Boulevard Philadelphia, PA 19104-6142, USA.


Recently a number of viruses, including a poxvirus, herpesvirus, retrovirus and two paramyxoviruses, have been shown to activate cells via Toll-like receptor family members. Here we postulate that although activation via Toll-like receptor molecules can lead to anti-viral innate immune responses, in some cases viruses may use these responses to ameliorate infection.

[Indexed for MEDLINE]

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