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Nat Med. 2003 Sep;9(9):1123-4. Epub 2003 Aug 24.

T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.

Author information

1
Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Göteborg, Sweden.

Abstract

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

PMID:
12937414
DOI:
10.1038/nm921
[Indexed for MEDLINE]

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