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FEBS Lett. 2003 Aug 28;550(1-3):1-4.

Membrane traffic fuses with cartilage development.

Author information

1
Biotechnology Research Institute, 6100 Royalmount Avenue, Montreal, QC, Canada H4P 2R2. michael.sacher@bri.nrc.ca

Abstract

The ability of cells to synthesize and secrete proteins is essential for numerous cellular functions. Therefore, when mutations in one component of the secretory pathway result in a tissue-specific defect, a unique opportunity arises to examine the molecular mechanisms at play. The recent finding that a defect in the protein sedlin, whose yeast counterpart is involved in the first step of the secretory pathway, leads to a cartilage-specific disorder in humans raises numerous questions and interesting possibilities for understanding both the pathobiology involved and the role of membrane traffic in normal cartilage development.

PMID:
12935876
DOI:
10.1016/s0014-5793(03)00854-8
[Indexed for MEDLINE]
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