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Infect Immun. 2003 Sep;71(9):5407-11.

Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii.

Author information

1
Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.

Abstract

Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.

PMID:
12933894
PMCID:
PMC187360
[Indexed for MEDLINE]
Free PMC Article

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