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Trends Biochem Sci. 2003 Aug;28(8):452-9.

Viruses and the 26S proteasome: hacking into destruction.

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International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy.


The discovery that the human papillomavirus E6 oncoprotein could direct the ubiquitination and degradation of the p53 tumour suppressor at the 26S proteasome was the beginning of a new view on virus-host interactions. A decade later, a plethora of viral proteins have been shown to direct host-cell proteins for proteolytic degradation. These activities are required for various aspects of the virus life-cycle from entry, through replication and enhanced cell survival, to viral release. As with oncogenes and cell-cycle control, the study of apparently simple viruses has provided a wealth of information on the function of a whole class of cellular proteins whose function is arguably as important as that of the kinases: the ubiquitin-protein ligases.

[Indexed for MEDLINE]

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