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Eur J Cancer. 2003 Sep;39(13):1828-34.

Small molecules that reactivate mutant p53.

Author information

1
Department of Oncology-Pathology, Cancer Center Karolinska, SE-171 76 Stockholm, Sweden.

Abstract

Around half of all human tumours carry mutant p53. This allows escape from p53-induced cell cycle arrest and apoptosis. Many tumours express mutant p53 proteins at elevated levels. Restoration of wild-type p53 function should trigger massive apoptosis in tumour cells and thus eradicate tumours. Various types of small molecules have been identified that can restore native conformation and wild-type function to mutant p53. Such molecules may serve as leads for the development of novel efficient anticancer drugs.

PMID:
12932659
DOI:
10.1016/s0959-8049(03)00454-4
[Indexed for MEDLINE]

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