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J Nat Prod. 2003 Aug;66(8):1104-6.

Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus.

Author information

1
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan.

Abstract

Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12 alpha,28-dihydroxy-3 alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)-dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema on mouse ears by 49-86% with a 400 nmol/ear application.

PMID:
12932134
DOI:
10.1021/np0300479
[Indexed for MEDLINE]
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