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Org Biomol Chem. 2003 Jan 7;1(1):17-20.

Detection of a metallo-beta-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups.

Author information

1
Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.

Abstract

A fluorescent probe for the detection of a metallo-beta-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3- mercaptopropionamide (Dansyl-C2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.

PMID:
12929381
[Indexed for MEDLINE]

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