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Neurobiol Aging. 2003 Nov;24(7):909-14.

Peripheral cytokine release in Alzheimer patients: correlation with disease severity.

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  • 1Department of Neurology, University of Milano-Bicocca, San Gerardo Hospital, via Donizetti, 106, Monza 20052 (MI), Italy.

Abstract

Various studies suggested that inflammation is involved in the pathogenesis of Alzheimer's disease (AD). We investigated cytokine release from LPS-stimulated blood cells of 32 AD patients, with different disease severity, compared to 16 age-related controls. A significant decrease of IL-1beta and IL-6 secretion was observed in severely demented patients; TNF-alpha release was also decreased, but not significantly. By contrast, mild and moderate patients showed a cytokine release similar to controls. IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression.

PMID:
12928049
[PubMed - indexed for MEDLINE]
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