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Drug Discov Today. 2003 Aug 1;8(15):701-9.

Molecular diversity through sugar scaffolds.

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1
Alchemia Pty Ltd, 3 Hi-Tech Court, Brisbane Technology Park, Eight Mile Plains QLD 4113, Australia. WMeutermans@alchemia.com.au

Abstract

Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.

PMID:
12927513
[Indexed for MEDLINE]

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