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Lancet. 2003 Aug 9;362(9382):449-50.

Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome.

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Nephrourology Unit, Institute of Child Health, London, UK.


In November, 1999, all children under age 18 years in the UK were offered immunisation with the newly introduced meningococcal C conjugate vaccine (MCCV). In a cohort of 106 patients with nephrotic syndrome, there were 63 relapses during the 12 months before vaccination, and 96 during the equivalent period postvaccination (p=0.009). The relapse rate of nephrotic syndrome increased significantly after administration of MCCV. Whether to vaccinate such children needs to be carefully considered.

[Indexed for MEDLINE]

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