Send to

Choose Destination
See comment in PubMed Commons below
Toxicol Lett. 2003 Oct 15;144(3):383-95.

Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening.

Author information

Center for Toxicology, University of Guelph, Bovey Building, Gordon Street, Guelph, Ont., Canada N1G 2W1.


The risks associated with occurrence of pharmaceuticals in water resources are mostly unknown. In the absence of extensive toxicological data, we scanned all the compounds observed in the environment for toxicological properties by (Quantitative) Structure Activity Relationship ((Q)SAR). The results of the probabilistic distribution of environmental and effect concentrations and hazard quotients (HQs) do not indicate significant acute risks prior to application of assessment factors. Compared with measured effect concentrations SAR predictions were more "sensitive" 80% of the time. The long-term effects of subtle and chronic changes, additive or synergistic effects and effects on other endpoints e.g. reproduction, behavior, metabolism, bacterial resistance etc. are still uncertain. (Q)SAR's can be important prioritization tools for subsequent experimental risk assessment of pharmaceuticals in surface waters, due to the prevalent lack of ecotoxicological data.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center