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J Am Chem Soc. 2003 Aug 27;125(34):10192-3.

Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media.

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MGH-Center for Molecular Imaging Research, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.


Monodisperse magnetic nanoparticles conjugated with virus-surface-specific antibodies self-assemble in the presence of specific viral particles to create supramolecular structures with enhanced magnetic properties, as detected by magnetic resonance methods (NMR/MRI). The observed magnetic relaxation changes that occur upon viral-induced assembly allowed for highly sensitive and selective detection of a virus in complex biological media. The developed method was shown to specifically detect adenovirus-5 and herpes simplex virus-1 at concentrations of 5 viral particles/10 muL without the need of extensive sample preparation. The applications of this new method span from high-throughput NMR detection of viruses in biological samples to potential MR imaging of viral distribution in vivo.

[Indexed for MEDLINE]

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