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Org Biomol Chem. 2003 May 21;1(10):1707-10.

Preparation and in vitro evaluation of GdDOTA-(BOM)4; a novel angiographic MRI contrast agent.

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1
Department of Medicinal Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1155, Blindern, N-0318 Oslo, Norway. ragnar.hovland@farmasi.uio.no

Abstract

A novel Gd(III) complex, GdDOTA-(BOM)4, has been prepared by a simple three-step procedure. The complex showed high T1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T1-relaxivity in plasma, 67.4 s-1 mM-1 (20 MHz, 37 degrees C), makes it a promising candidate for angiographic applications of MRI.

PMID:
12926358
[Indexed for MEDLINE]
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