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Mamm Genome. 2003 Jul;14(7):448-53.

A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.

Author information

1
MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK. paul@har.mrc.ac.uk

Abstract

We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.

PMID:
12925893
DOI:
10.1007/s00335-002-2261-9
[Indexed for MEDLINE]
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