The article is dealt with organization of agencies of U.S. federal government responsible for control of food safety and quality. An organizational chart of the Food and Drug Administration (FDA) of Department of Health and Human services is shown in great details. The U.S. federal legislation on food safety and quality is also described. Legal terms and definitions set by Federal Food, Drug and Safety Act for food safety and quality as well as basis requirements set in U.S.A. for food operation facilities are also discussed.