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Nat Rev Mol Cell Biol. 2003 Aug;4(8):651-7. doi: 10.1038/nrm1173.

Transactivation joins multiple tracks to the ERK/MAPK cascade.

Author information

1
Institute for Molecular Cell Biology, Jena University Hospital, Drackendorfer Strasse 1, D-07747 JENA, Germany. i5rewe@rz.uni-jena.de

Abstract

Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.

PMID:
12923527
DOI:
10.1038/nrm1173
[Indexed for MEDLINE]

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