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Nat Rev Mol Cell Biol. 2003 Aug;4(8):613-20.

Chromatin assembly by DNA-translocating motors.

Author information

1
Section of Molecular Biology, University of California, 9500 Gilman Drive, La Jolla, San Diego, California 92093-0347, USA.

Abstract

Chromatin assembly is required for the duplication of eukaryotic chromosomes and functions at the interface between cell-cycle progression and gene expression. The central machinery that mediates chromatin assembly consists of histone chaperones, which deliver histones to the DNA, and ATP-utilizing motor proteins, which are DNA-translocating factors that act in conjunction with the histone chaperones to mediate the deposition of histones into periodic nucleosome arrays. Here, we describe these factors and propose possible mechanisms by which DNA-translocating motors might catalyse chromatin assembly.

PMID:
12923523
DOI:
10.1038/nrm1177
[Indexed for MEDLINE]

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