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Heart. 2003 Sep;89(9):993-7.

Inflammatory and thrombotic mechanisms in coronary atherosclerosis.

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1
Cardiology Unit, Athens University Medical School, Athens, Greece. drtousoulis@hotmail.com

Abstract

Many molecular and cellular mechanisms link inflammation and haemostatic mechanisms. Inflammation, and perhaps chronic infection, may play important roles in the initiation and progression of atherosclerosis. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation (macrophages and T lymphocytes), and acute plaque rupture is also associated with inflammatory components. Several markers of systemic inflammation may predict future cardiovascular events in apparently healthy subjects as well as in patients with chronic and acute syndromes. There may thus be therapeutic potential in modifying the atherosclerotic, vasomotor, and thrombotic components of ischaemic heart disease.

PMID:
12923007
PMCID:
PMC1767836
[Indexed for MEDLINE]
Free PMC Article
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