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Leuk Res. 2003 Dec;27(12):1159-62.

Constitutive phosphorylation of FKHR transcription factor as a prognostic variable in acute myeloid leukemia.

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1
Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, South Korea.

Abstract

The transcription factor FKHR, which is controlled by Akt-PKB signaling, is involved in regulating cell cycle progression and cell death. In this study, the phosphorylation of FKHR was observed in 45 (73.8%) of 61 patients with acute myeloid leukemia (AML). The phosphorylation of Akt-PKB was found to be significantly associated with phospho-FKHR (P<0.001). Patients with phospho-FKHR had a significantly shorter overall survival than those without (P<0.05). In conclusion, the constitutive phosphorylation of FKHR was observed in the majority of AML, and the detection of phospho-FKHR might provide a new tool for identifying AML patients with an unfavorable outcome.

PMID:
12921955
DOI:
10.1016/s0145-2126(03)00102-4
[Indexed for MEDLINE]

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