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Zhonghua Zhong Liu Za Zhi. 2003 Jul;25(4):325-7.

[D-limonene induces apoptosis of gastric cancer cells].

[Article in Chinese]

Author information

1
Department of General Surgery, Fourth Hospital of Dalian Medical University, Dalian 116001, China.

Abstract

OBJECTIVE:

To investigate the apoptosis effect induced by D-limonene on BGC-823 gastric cancer cells.

METHODS:

The expression of p53, bc1-2 in BGC-823 cells and qualitative, quantitative index of cell apoptosis were detected with MTT, electron microscopy, flow cytometry and immunohistochemical method.

RESULTS:

D-limonene could induce the formation of apoptotic bodies in a dose- and time-dependent manner. The expression of bcl-2 protein decreased and p53 protein increased in BGC-823 cells treated with D-limonene, compared with the control cells.

CONCLUSION:

D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.

PMID:
12921557
[Indexed for MEDLINE]

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