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Pharmacotherapy. 2003 Aug;23(8):988-91.

Pharmacokinetics of meropenem 0.5 and 2 g every 8 hours as a 3-hour infusion.

Author information

1
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.

Abstract

STUDY OBJECTIVE:

To assess the pharmacokinetics of meropenem administered as a 3-hour infusion.

DESIGN:

Randomized, crossover, open-label study.

SETTING:

Clinical research center.

SUBJECTS:

Six healthy adult male volunteers.

INTERVENTION:

Each subject received meropenem 0.5 or 2 g every 8 hours as a 3-hour infusion for three doses and then crossed over to the other dosage regimen.

MEASUREMENT AND MAIN RESULTS:

Pharmacokinetic parameters of both regimens were compared, and no significant differences between 0.5- and 2-g doses for the dose-independent parameters (half-life, clearance, and volume of distribution at steady state) were observed. The regimens displayed dose proportionality and were consistent with that of a traditional 0.5-hour infusion. The 3-hour infusion optimized the pharmacodynamic profile of meropenem and worked within the constraints of stability at room temperature stability.

CONCLUSION:

Prolonging the percentage of time above the minimum inhibitory concentration is a feasible option with meropenem; however, further studies are needed to quantify how this increase translates to efficacy.

PMID:
12921245
[Indexed for MEDLINE]

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