Format

Send to

Choose Destination
Dev Cell. 2003 Aug;5(2):197-203.

A metabolic model for life span determination in Caenorhabditis elegans.

Author information

1
Institute for Behavioral Genetics, University of Colorado, Boulder, 1480 30th Street, Boulder, CO 80309, USA. srea@colorado.edu

Abstract

Several studies with the nematode Caenorhabditis elegans have made the unexpected discovery that certain hypomorphic mutations in genes encoding mitochondrial proteins result in life span extension. These mutations appear to act independently of the other known pathway that regulates life span extension, the dauer-specifying insulin/IGF-1-like pathway. Here we present a hypothesis that unifies the effects of these two classes of genes on longevity. The central concept is that energy generation in C. elegans occurs by differential flux through two coexisting mitochondrial metabolic pathways-aerobic respiration and fermentative malate dismutation. In the latter process, fumarate is terminally reduced at complex II to succinate. We suggest that most, if not all, long-lived mutants in C. elegans utilize malate dismutation, a byproduct of which is the generation of fewer radical species.

PMID:
12919672
DOI:
10.1016/s1534-5807(03)00242-9
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center