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Epilepsia. 2003 Sep;44(9):1238-40.

Nicotine as an antiepileptic agent in ADNFLE: an N-of-one study.

Author information

1
Centre for Neuroscience and Department of Medicine (Neurology) School of Informatics and Engineering Division of Pharmacy, Flinders University and Medical Centre, Adelaide, South Australia, Australia. John.@Willoughby@flinders.edu.au

Erratum in

  • Epilepsia. 2003 Oct;44(10):1363.

Abstract

PURPOSE:

To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy.

METHODS:

Open and double-blind trials of nicotine patches in an "n-of-one" study. The double-blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double-blind manner.

RESULTS:

In an open study, nicotine patches reduced seizures from 1.65 +/- 2.36 to 0.01 +/- 0.0 seizures per day (p < 0.0001). In a double-blinded placebo-controlled phase, the average frequency of seizures on nicotine versus placebo was 0 +/- 0 versus 0.56 +/- 1.14 seizures per day (p < 0.0001).

CONCLUSIONS:

Nicotine patches may be of benefit to some individuals with ADNFLE.

PMID:
12919397
[Indexed for MEDLINE]
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