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Nutr Rev. 2003 Jul;61(7):255-8.

Mouse models of gastrointestinal tumorigenesis for dietary cancer prevention studies.

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Strang Cancer Research Laboratory, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.


Mouse models have been generated to help identify dietary components that are protective against gastrointestinal tumorigenesis. Some of the models are produced by gene-targeting procedures, whereas others use the normal mouse as an experimental animal. These preclinical mouse models have provided valuable information on the chemopreventive efficacy of specific nutrients greatly enhancing our understanding of the molecular mechanisms involved in gastrointestinal tumorigenesis.

[Indexed for MEDLINE]

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