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Nutr Rev. 2003 Jul;61(7):247-9.

Zinc regulation of food intake: new insights on the role of neuropeptide Y.

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Florida State University, Program in Neuroscience, Department of Nutrition, Food & Exercise Sciences, 237 Biomedical Research Facility, Tallahassee, FL 32306-4340, USA.


The role of neuropeptide Y (NPY) in feeding behavior and zinc deficiency-induced anorexia has been controversial because hypothalamic NPY levels are elevated in both zinc deficiency and food restriction. A recent report shows that while NPY is released from terminals in the paraventricular nucleus of the hypothalamus of food-restricted animals, this release is significantly impaired in zinc-deficient animals. Zinc deficiency may therefore cause anorexia by inhibiting the release of NPY that is required for receptor activation.

[Indexed for MEDLINE]

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