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Biochim Biophys Acta. 2003 Aug 18;1641(2-3):111-9.

Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins.

Author information

1
Biochemie Zentrum Heidelberg (BZH), University of Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany. cu2@ix.urz.uni-heidelberg.de

Abstract

SNARE proteins function at the center of membrane fusion reactions by forming complexes with each other via their coiled-coil domains. Several SNAREs have N-terminal domains (NTDs) that precede the coiled-coil domain and have critical functions in regulating the fusion cascade. This review will highlight recent findings on NTDs of syntaxins, the longin domain of VAMP proteins and SNAP-23/25 homologues in yeast. Biochemical and genetic experiments as well as the resolution of several NMR and crystal structures of SNARE NTDs shed light on their diverse function.

PMID:
12914952
DOI:
10.1016/s0167-4889(03)00094-6
[Indexed for MEDLINE]
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