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Chest. 2003 Aug;124(2):740-3.

Statins, inflammation, and sepsis: hypothesis.

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1
Medical Intensive Care Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel. almogya@bgumail.bgu.ac.il

Abstract

Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

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PMID:
12907568
[Indexed for MEDLINE]
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