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Reg Immunol. 1992 Sep-Oct;4(5):263-73.

Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice.

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Jackson Laboratory, Bar Harbor, ME 04609.


Genetically-controlled defects in the development and function of antigen presenting cells may explain why NOD mice exhibit an impaired ability to induce tolerance and/or activate immunoregulatory T cells. These defects provide understanding for why diabetogenesis in NOD mice is so sensitive to immunomodulatory changes mediated through the environment. Although the unique MHC haplotype of NOD mice is clearly a major contributor to diabetes susceptibility, evidence for a complex interaction between MHC loci and many other polygenetic factors is reviewed.

[Indexed for MEDLINE]

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