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Phys Rev Lett. 2003 Jul 4;91(1):018102. Epub 2003 Jul 1.

Adherence of packing defects in soluble proteins.

Author information

1
Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA. ariel@uchicago.edu

Abstract

For protein structure to prevail in water, its backbone hydrogen bonds must be shielded from water attack, requiring a cluster of "wrapping" nonpolar groups. Thus, underwrapped regions are adhesive, as exogenous removal of surrounding water becomes thermodynamically favorable. Here we measure the average adhesive force exerted by an underwrapped hydrogen bond on a test hydrophobe and thus define a new interactivity constant.

PMID:
12906578
DOI:
10.1103/PhysRevLett.91.018102
[Indexed for MEDLINE]

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