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J Endocrinol Invest. 2003 May;26(5):453-7.

Interleukin-6 producing pheochromocytoma presenting with acute inflammatory syndrome.

Author information

1
Department of clinical and Biological Sciences, General Medical Clinic, San Luigi Hospital, Orbassano (TO), Italy. marcominetto@libero.it

Abstract

Pheochromocytomas are tumors able to produce catecholamines and a variety of biologically active neuropeptides. We report the case of a 36-yr-old female patient with pheochromocytoma exhibiting headache, intermittent fever, thrombocytosis, and marked inflammatory signs. Nonsteroidal anti-inflammatory drugs were ineffective in lowering the body temperature, while a corticosteroid agent obtained excellent results. IL-6 was found elevated (20 pg/ml); it fell to 4.5 pg/ml 3 weeks after the adrenalectomy, in parallel to normalization of other laboratory data. The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine. To our knowledge, our paper represents the 6th case report of IL-6 secreting pheochromocytoma associated with clinical markers of inflammatory response.

PMID:
12906374
DOI:
10.1007/BF03345202
[Indexed for MEDLINE]

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