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[Expression of inducible nitric oxide synthase in human esophageal biopsies from carcinoma and precancerous lesions].

[Article in Chinese]

Author information

1
Detection Center of Tumor Biology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.

Abstract

OBJECTIVE:

To investigate the possible role of inducible nitric oxide synthase (iNOS) in esophageal carcinogenesis.

METHODS:

iNOS expressions in normal epithelial cells(NC), hyperplastic cells(HC), atypical hyperplastic cells(AHC) from grade I to III, carcinoma in situ(CIS), squamous cell carcinoma(SCC), and adenocarcinoma(ADC) were detected with immunohistochemistry.

RESULTS:

The positive rates of immunohistochemistry staining was 0 for NC, 2.5% for HC, 4.0%, 7.5% and 2.5% for AHC grade I to III respectively, 1.4% for CIS, 8.5% for SCC and 71.4% for ADC.

CONCLUSIONS:

There is a high expression of iNOS in human esophageal adenocarcinomas. Frequent expression of iNOS may be a potential event in ADC carcinogenesis. There is no correlation between iNOS and SCC carcinogenesis.

PMID:
12903407
[Indexed for MEDLINE]

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