Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy

Y Kubota; S Tani; R Uchida

doi:10.1093/nass/44.1.235

Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy

Nucleic Acids Symp Ser. 2000:(44):235-6. doi: 10.1093/nass/44.1.235.

Authors

Y Kubota¹, S Tani, R Uchida

Affiliation

¹ Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.

PMID: 12903355
DOI: 10.1093/nass/44.1.235

Abstract

The solution structures of 1:1 complexes of a quinacrine-netropsin hybrid molecule with the self-complementary DNA duplexes, d(CGCGAATTCGCG)2 and d(CGAATTCG)2, have been studied by one- and two-dimensional 1H NMR spectroscopy. The NOE data indicate that the acridine ring of the hybrid intercalates into the 5'-GpA step and its netropsin moiety spans the minor groove of the central AATT region.

MeSH terms

Base Sequence
DNA / chemistry*
Intercalating Agents / chemistry*
Molecular Structure
Netropsin / analogs & derivatives*
Netropsin / chemistry
Nuclear Magnetic Resonance, Biomolecular
Oligodeoxyribonucleotides / chemistry
Protons
Quinacrine / analogs & derivatives*
Quinacrine / chemistry
Solutions

Substances

Intercalating Agents
Oligodeoxyribonucleotides
Protons
Solutions
Netropsin
DNA
Quinacrine