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Nucleic Acids Res Suppl. 2002;(2):291-2.

An anthracene derivative carrying ferrocenyl moieties at its 9 and 10 positions as a new electrochemically active threading intercalator.

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Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.


A ferrocenyl anthracene derivative (FAN) was synthesized by connecting ferrocene moieties to the amino termini of its substitutents at 9 and 10 positions, aiming at an improved hybridization indicator. Spectrophotometric experiments revealed that FAN can bind to double stranded DNA (dsDNA) by threading intercalation. Evaluation of FAN in the dsDNA preference as hybridization indicator revealed that FAN has higher preference for dsDNA than ferrocenyl naphthalene diimdie (FND) reported previously.

[Indexed for MEDLINE]

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