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Virus Res. 2003 Aug;94(2):97-101.

High prevalence of an IgG response against murine leukemia virus (MLV) in patients with psoriasis.

Author information

1
Laboratoire de Dermatologie Moléculaire, Institut Universitaire de Recherche Clinique, 641 avenue du Doyen G. Giraud, 34 093 Montpellier, cedex 5, France. jpm@iurc.montp.inserm.fr

Abstract

Increasing evidence suggests that human endogenous retroviruses (HERV) could participate in the pathogenesis of autoimmune diseases such as multiple sclerosis and lupus erythematosus. To assess a possible association of murine leukemia virus (MLV)-like group of HERVs with psoriasis we searched for antibodies against MLV proteins in the sera of patients. We showed that anti-MLV antibodies (total) were detected in both psoriatic and control sera. However, they were detected with a higher frequency in psoriasis when compared with controls (91 vs. 53%, respectively, P=0.001). In addition, the IgG response was dramatically increased in psoriasis (86 vs. 8%, respectively, P<0.0001). This immunoreactivity was observed against the products of both the gag and env genes, and the most antigenic proteins were the gp65-70. Moreover, we observed that anti-p30 MLV antibodies reacted with an epidermal protein with a molecular weight of 50 kDa in protein extracts from both normal and psoriatic skin cultures. These observations suggest that HERVs of the MLV-like group could contribute to the immunopathogenesis of psoriasis.

PMID:
12902038
[Indexed for MEDLINE]

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