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Curr Opin Pharmacol. 2003 Aug;3(4):344-51.

Histone deacetylases.

Author information

1
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. munroed@mskcc.org

Abstract

Post-translational modification of the histones of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules. These histone deacetylase inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. Results of clinical trials with several of these agents have indicated that they are well tolerated at doses that have anti-tumour activity.

PMID:
12901942
DOI:
10.1016/s1471-4892(03)00084-5
[Indexed for MEDLINE]

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