Send to

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2003 Aug;19(8):349-55.

The first releases of transgenic mosquitoes: an argument for the sterile insect technique.

Author information

Entomology Unit, Food and Agriculture Organization/International Atomic Energy Agency Agriculture and Biotechnology Laboratory, Agency's Laboratories Seibersdorf, A-1400 Vienna, Austria.


Potential applications for reducing transmission of mosquito-borne diseases by releasing genetically modified mosquitoes have been proposed, and mosquitoes are being created with such an application in mind in several laboratories. The use of the sterile insect technique (SIT) provides a safe programme in which production, release and mating competitiveness questions related to mass-reared genetically modified mosquitoes could be answered. It also provides a reversible effect that would be difficult to accomplish with gene introgression approaches. Could new technologies, including recombinant DNA techniques, have improved the success of previous mosquito releases? Criteria for an acceptable transgenic sterile mosquito are described, and the characteristics of radiation-induced sterility are compared with that of current transgenic approaches. We argue that SIT using transgenic material would provide an essentially safe and efficacious foundation for other possible approaches that are more ambitious.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center