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Biochem Biophys Res Commun. 2003 Aug 22;308(2):234-9.

Characterisation of CadR from Pseudomonas aeruginosa: a Cd(II)-responsive MerR homologue.

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Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.


cadR from Pseudomonas aeruginosa encodes a transcriptional regulatory protein which responds to Cd(II)>>Zn(II)>Hg(II) at its cognate promoter PcadA. CadR will also act to induce transcription at the Escherichia coli ZntR cognate promoter, PzntA, however, the induction profile is altered to Hg(II)>Cd(II)>Zn(II). Two separate single base pair deletions within PzntA result in further alteration of relative specificity in metal-ion induction profile for CadR. This demonstrates that the operator/promoter sequence can play a role in defining optimal ligand response and that for these regulators specificity is not solely a function of the regulatory protein.

[Indexed for MEDLINE]

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