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Curr Opin Immunol. 2003 Aug;15(4):416-20.

The role of dendritic cell subsets in immunity to viruses.

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Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.


Dendritic cells orchestrate the adaptive immune response. As well as presenting MHC-restricted antigen for T-cell activation, they provide all the co-receptor signals required for full T-cell priming. As a consequence, they play a central role in the immune response to infections caused by many pathogenic agents, including viruses. In recent times, it has become apparent that dendritic cells represent a particularly heterogeneous population with individual subsets playing specialized roles in response to infection.

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