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Trends Neurosci. 2003 Aug;26(8):397-400.

Does neurofilament phosphorylation regulate axonal transport?

Author information

1
Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA. thomas_shea@uml.edu

Abstract

Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.

PMID:
12900166
DOI:
10.1016/S0166-2236(03)00199-1
[Indexed for MEDLINE]

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