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Emerg Infect Dis. 2003 Jul;9(7):800-9.

Emergence and global spread of a dengue serotype 3, subtype III virus.

Author information

1
University of North Carolina, Chapel Hill, North Carolina, USA.

Abstract

Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.

PMID:
12899133
PMCID:
PMC3023445
DOI:
10.3201/eid0907.030038
[Indexed for MEDLINE]
Free PMC Article

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