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J Clin Invest. 2003 Aug;112(3):323-6.

Endocannabinoids and the regulation of body fat: the smoke is clearing.

Author information

1
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. tamas.horvath@yale.edu

Abstract

Endocannabinoids, endogenous ligands of cannabinoid receptor type 1 (CB1), have emerged as novel and important regulators of energy homeostasis. A report in this issue demonstrates reduced body weight, fat mass, and appetite in CB1-/- mice. Examination of the underlying mechanisms reveals a dual role for endocannabinoids as they affect both appetite and peripheral lipolysis.

PMID:
12897199
PMCID:
PMC166302
DOI:
10.1172/JCI19376
[Indexed for MEDLINE]
Free PMC Article

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