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BMJ. 2003 Aug 2;327(7409):254.

Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India.

Author information

1
Aravind Centre for Women, Children and Community Health, Madurai, Tamil Nadu, India.

Abstract

OBJECTIVE:

To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months.

DESIGN:

Community based, randomised, double blind, placebo controlled trial.

SETTING:

Two rural districts of Tamil Nadu, southern India.

PARTICIPANTS:

11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery.

MAIN OUTCOME MEASURE:

Primary outcome measure was mortality at age 6 months.

RESULTS:

Infants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months.

CONCLUSION:

Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.

PMID:
12896935
PMCID:
PMC167159
DOI:
10.1136/bmj.327.7409.254
[Indexed for MEDLINE]
Free PMC Article
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