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BMJ. 2003 Aug 2;327(7409):251-4.

Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study.

Author information

  • 1School of Medicine, Infection Inflammation and Repair Research Division, University of Southampton, Southampton General Hospital, Southampton SO16 6YD. michael@radcliffe.net

Abstract

OBJECTIVE:

To assess the efficacy of enzyme potentiated desensitisation in the treatment of severe summer hay fever poorly controlled by pharmacotherapy.

DESIGN:

Double blind randomised placebo controlled parallel group study.

SETTING:

Hospital in Hampshire.

PARTICIPANTS:

183 participants aged between 18 and 64 with a history of severe summer hay fever for at least two years; all were skin prick test positive to timothy grass pollen. 90 randomised to active treatment; 93 randomised to placebo.

INTERVENTIONS:

Active treatment: two injections of enzyme potentiated desensitisation, given between eight and 11 weeks apart, each comprising 200 Fishman units of beta glucuronidase, 50 pg 1,3-cyclohexanediol, 50 ng protamine sulphate, and a mixed inhaled allergen extract (pollen mixes for trees, grasses, and weeds; allergenic fungal spores; cat and dog danders; dust and storage mites) in a total volume of 0.05 ml of buffered saline. Placebo: two injections of 0.05 ml buffered saline solution.

MAIN OUTCOME MEASURES:

Proportion of problem-free days; global rhinoconjunctivitis quality of life scores assessed weekly during pollen season.

RESULTS:

The active treatment group and the placebo group did not differ in the proportion of problem-free days, quality of life scores, symptom severity scores, change in quantitative skin prick provocation threshold, or change in conjunctival provocation threshold. No clinically significant adverse reactions occurred.

CONCLUSIONS:

Enzyme potentiated desensitisation showed no treatment effect in this study.

PMID:
12896934
PMCID:
PMC167158
DOI:
10.1136/bmj.327.7409.251
[PubMed - indexed for MEDLINE]
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