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Environ Health Perspect. 2003 Aug;111(10):1391-401.

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.

Author information

1
School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, England. m.t.cronin@livjm.ac.uk

Abstract

This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.

PMID:
12896862
PMCID:
PMC1241622
[Indexed for MEDLINE]
Free PMC Article

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