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J Reprod Immunol. 2003 Aug;59(2):245-51.

The birth interval hypothesis-does it really indicate the end of the primipaternity hypothesis.

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Department of Obstetrics and Gynaecology, University of Adelaide, Lyell McEwin Hospital, SA 5112 Elizabeth Vale, Australia.


Recent Norwegian data suggest the presence of a causal relationship between prolonged birth intervals and the risk for preeclampsia in subsequent pregnancies. It has been proposed that the birth interval data explain the known association between a change in paternity and the risk for preeclampsia. In this review, the authors explore alternative explanations for the Norwegian findings, and as such argue that there is currently no reason to reject the primipaternity hypothesis.

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